With manager James Rowe suspended due to allegations of misconduct, first-team coach Danny Webb will lead the Spireites at the Silverlake Stadium.
Town slipped to second in the table in midweek and could find themselves further down the league by the time this one kicks-off at 5.20pm.
Eastleigh sacked manager Ben Strevens on Wednesday following some poor results.
Here’s Liam Norcliffe’s predicted Spireites line-up...
Eastleigh sacked manager Ben Strevens on Wednesday following some poor results.
5. Tyrone Williams - RWB
Williams has been used in the right wing-back role at times this season and I can see that happening again with King suspended. With it being an away game, I think he is the more likely one to fill that slot. Photo: Jason Chadwick
7. Manny Oyeleke - CM
The midfielder is a doubt for this one but that has been the case several times this season and he has played. Photo: Tina Jenner
8. Alex Whittle - LWB
Continues to be impress whether it be from the start or off the bench. Photo: Tina Jenner