With manager James Rowe suspended due to allegations of misconduct, first-team coach Danny Webb will lead the Spireites at the Silverlake Stadium.
Town slipped to second in the table in midweek and could find themselves further down the league by the time this one kicks-off at 5.20pm.
Eastleigh sacked manager Ben Strevens on Wednesday following some poor results.
Here’s Liam Norcliffe’s predicted Spireites line-up...
Eastleigh sacked manager Ben Strevens on Wednesday following some poor results.
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