The Spireites produced a brilliant performance in midweek to overcome Notts County which left them three points behind leaders Stockport County.
Town have already beaten Southend twice this season but the Shrimpers have been transformed under Kevin Maher and they have gone from relegation strugglers to having an outside chance of the play-offs.
Maher’s men are unbeaten in their last 11 games in the league so they will be a tough nut to crack.
Here’s how Liam Norcliffe thinks Chesterfield will line-up...
5. Calvin Miller - LB
Alex Whittle was forced off with a slight groin injury on Tuesday night so Miller will probably continue in the left-back role. Photo: Tina Jenner
6. Jim Kellermann - CM
He was one of the stand-out performers against the Magpies. Photo: Tina Jenner
7. Tom Whelan - CM
Made a very impressive return to the Spireites so far. Photo: Tina Jenner
8. Liam Mandeville - AMR
Rose to the occasion in the second-half against Notts and helped swing the game in Town's favour. Photo: Tina Jenner