The Spireites produced a brilliant performance in midweek to overcome Notts County which left them three points behind leaders Stockport County.
Town have already beaten Southend twice this season but the Shrimpers have been transformed under Kevin Maher and they have gone from relegation strugglers to having an outside chance of the play-offs.
Maher’s men are unbeaten in their last 11 games in the league so they will be a tough nut to crack.
Here’s how Liam Norcliffe thinks Chesterfield will line-up...
14. Curtis Weston - sub
Back from suspension after completing a three-match ban. Photo: Tina Jenner
15. Tom Denton - sub
Not involved against Notts due to an ankle knock but could be back for this one. Photo: Tina Jenner
16. Joe Quigley - sub
Will be hoping to get off the mark for the first time in a Spireites shirt sooner rather than later. Photo: Tina Jenner