The Spireites are sixth in the table, two points off third, while their next opponents are 18th, but come into it on the back of an impressive 4-1 win at Bristol Rovers.
With a couple of players back from suspension and one possibly available again after injury, manager Paul Cook has got some selection headaches for this weekend.
Let’s take a look at how they could line-up...
1. Zach Hemming - GK
Two important saves in the last two matches have ensured Chesterfield have come away from them with four points. Photo: Leila Coker
2. Vontae Daley-Campbell - RB
He was suspended last weekend but his form this season should see him return. His physical attributes against an aggressive side could be useful. Photo: Brian Eyre
3. Chey Dunkley - CB
The centre-back has put the Colchester wobble behind him with two dominant performances in the last two league matches. Photo: Brian Eyre
4. Kyle McFadzean - CB
Like Dunkley, McFadzean has also put in successive impressive displays, winning one of the man of the match award last time out. Photo: Tina Jenner