Ryan Boot saved a penalty from Omari Patrick after Kyle McFadzean was punished for a foul and the hosts made the visitors pay just before half-time when Tom Naylor headed in James Berry’s inviting cross.
But Sam Finley equalised on 53 minutes, applying a first-time finish from inside the area, which was Tranmere’s first goal in six matches.
Naylor went close with two more headers late on but the Spireites did not do enough to deserve all three points against a Tranmere side who had lost nine of their previous 10 games.
The result means Chesterfield stay seventh in League Two.
Here are our player ratings from the game...
13. Lewis Gordon 6
Lewis Gordon 6 Made his first appearance since the end of December after returning from injury, replacing Owolabi-Belewu at half-time. Photo: Tina Jenner
15. John Fleck 6
John Fleck 6 Back in the action after months out, replacing Berry on 75. Photo: Brian Eyre
