Having made the play-offs last season, the Spireites are one of the favourites for promotion again.
James Rowe has made several new signings, and many of them are expected to start at The EBB Stadium.
Saturday will be the first time Chesterfield fans have been allowed into an away ground for a league game since March 2020.
Here's how our reporter Liam Norcliffe thinks the Blues could line-up this weekend...
Saturday will be the first time Chesterfield fans have been allowed into an away ground for a league game since March 2020.