Both sides have collected four points from their first two games so far.
The Spireites and the Red Dragons both lost in the play-offs last season.
Wrexham won this fixture 2-0 last time.
Here’s how we think Chesterfield could line-up...
1. Ross Fitzsimons - GK
He has started the last 12 consecutive games and there's no reason to think he won't do again. Photo: Pete Norton
2. Jeff King - RB
His assist at the weekend took him to seven for the season, as well as his seven goals. Photo: Tina Jenner
3. Ash Palmer - CB
Made his first start on Saturday since signing from Stockport County and put in a solid display. Photo: Tina Jenner
4. Jamie Grimes - CB
He has still played every minute of every game this season. Photo: Tina Jenner
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