The road is closed and police say it will remain closed for some time.
Drivers are advised to avoid the area and find alternative routes – traffic is currently backing up around Whittington Moor.
A witness who was at the Glass Yard, on Sheffield Road, said a car had gone through a window.
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The Derbyshire Times has been informed that people have also been evacuated from businesses in the area.
The Air Ambulance service and fire service are also at the scene.
A spokesman from Derbyshire Constabulary said they could not comment further at this time.
More to follow.