The Spireites will be aiming to bounce back after losing 3-1 at Woking a week ago.
The hosts, meanwhile, saw their game at Aldershot on Saturday abandoned in the second-half due to a waterlogged pitch when they were winning 2-0.
Town are currently are third in the table, while Wrexham are 12th.
Liam Norcliffe is at the game and will have all the build-up, team news, updates and reaction.
Wrexham v Chesterfield: LIVE UPDATES
Last updated: Wednesday, 06 October, 2021, 11:47
- FT: Wrexham 1 v 1 Chesterfield (7.45pm KO)
- Fraser Kerr gives Town lead on six minutes
- Kabongo Tshimanga has penalty saved before half-time
- Paul Mullin heads equaliser on 84 minutes
- Four changes for Chesterfield as Maguire, Kellermann, Carline and Rowe replace Grimes, McCourt, Mandeville and Payne
- Loach; Kerr, Gunning, Maguire; King, Weston, Kellermann, Carline; Khan; Rowe, Tshimanga. Subs: Grimes, Miller, Whittle, Mandeville, Payne
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A strong performance from Town and they deserved much more than a point.
Southend United away on Saturday next up.
Chesterfield put in a much-improved performance but had to settle for a draw against Wrexham at the Racecourse Ground on Tuesday night.
Dominance, a bad injury and the late show - five big talking points from Chesterfield's draw at Wrexham
Chesterfield’s George Carline suffered a suspected broken knee cap as the Spireites were undeservedly held to a late draw against Wrexham.
WREXHAM REACTION: Rowe: 'We absolutely battered them'| Bad news as Carline suffers suspected broken knee cap
James Rowe said Chesterfield ‘absolutely battered’ Wrexham and that the result was ‘shambolic’ as the dominant Spireites had to settle for a point after conceding another late goal.
It ends in a draw
FT: Wrexham 1 v 1 Chesterfield
A really good response from the Spireites tonight after last week. Deserved more. Plenty of positives, but another late goal conceded.
Wrexham hit the crossbar
Hayden crashes one against the crossbar. Very close.
Payne is booked. I make this his fifth of the season and will miss Southed on Saturday.
Six minutes added
Final Spireites sub - 90 minutes
Carline is stretchered off and is replaced by Whittle. Going to be a lot of added time now.
Carline has gone down in pain and the stretcher has been called for. This does not look good.