Here we take a look at the former St Mary's Catholic High School pupil's rise through the ranks of Sheffield United, Hull City, Wigan Athletic, Leicester City and Manchester United - as well as a glimpse of his international exploits with England.
Maguire played a handful of games at the back end of the 2010/11 season for Sheffield United but it was the next campaign which saw him nail down a first team spot, going on to make 56 appearances in 2011/12.
He was a consistent performer for the Blades as they looked to get back into the Championship. He was named in the PFA League One team of the season in 2012, 2013 and 2014.
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This didn't go unnoticed and soon clubs were sniffing, with Premier League side Hull City winning the race for his signature in the summer of 2014 for a crisp 2.5m. Maguire made his debut for the Tigers in the Europa League.
He went out on loan in the second half of that season to Wigan Athletic, of the Championship, making 16 appearances for the Latics.
He helped Hull back to the Premier League in 2015/16 and played 36 times in all competitions the following season, which included a goalless draw at Old Trafford, but ultimately ended in relegation for the Tigers.
Maguire was in-demand though and Leicester City shelled out 17m for the defender in 2017. He played every minute of that campaign for the Foxes and won the Player of the Season and Players' Player vote.
England came calling and Maguire made his international debut in the 1-0 World Cup qualifying win over Lithuania in October 2017. He went on to play for Gareth Southgate's side at the 2018 World Cup.
He was an ever-present during the competition, as England made it to the semi-finals for the first time since 1990. Maguire scored in the 2-0 quarter-final win over Sweden. Southgate's side were knocked out by Croatia in the semis.
The tournament saw Maguire's stock rise once more, with speculation mounting of interest from then-Manchester United boss Jose Mourinho. Maguire stayed with Leicester and enjoyed another fruitful campaign.
The former Chesterfield schoolboy finally made his Old Trafford move for a record-breaking 85m this summer and starred on his Red Devils debut on Sunday, in a 4-0 win over Chelsea.