Ollie Banks has been given the nod by Spireites boss Paul Cook to replace the suspended Sam Morsy in the Chesterfield midfield.
It is an otherwise unchanged side to that which registered a goalless draw against Crewe Alexandra seven days previous at Gresty Road.
Charlie Raglan continues at centre-back alongside skipper Ian Evatt, as the Spireites look to build on three consecutive clean sheets.
Armand Gnanduillet, who returned from his loan spell at Tranmere Rovers this week, will have to settle for a place on the bench alongside Georg Margreitter.
A first league win since October 4, when Chesterfield overcame Sheffield United, is in Chesterfield’s sights against an in-form Barnsley.
Danny Wilson’s Tykes are unbeaten in their last three - a derby win over the Blades at Bramall Lane proving a catalyst for their up-turn of late.
Chesterfield: Lee; Darikwa, Evatt, Raglan, Jones; Ryan, Banks; O’Shea, Roberts, Clucas; Doyle
Subs: Wright; Margreitter, Humphreys, Boco, Gardner, Ariyibi, Gnanduillet
Barnsley: Turnbull; Dudgeon, Berry, Nyatanga, Cranie, Hourihane, Winnall, Hemmings, Ramage, Bailey, Cole
Subs: Treacy, Digby, M’Voto, Abbott, Trotta, Lita, Davies
Referee: Andre Marriner (West Midlands).