Danny Wilson expects a tough Easter campaign and says squad management will be crucial to a healthy points return.
The Spireites host Fleetwood on Saturday before travelling to Oldham on Easter Monday.
Wilson, whose side put on a much-improved second half showing to earn a point at Scunthorpe in their last outing, says the double-bill of games presents his side with a great opportunity to further extend the cushion between themselves and the bottom four.
“There’s a fantastic chance to open up a gap,” said Wilson.
“It’s a big game for us and a big game for Fleetwood as well.
“The Oldham game will look after itself when it comes around.
“We’ll take stock of what’s available to us for that game, player-wise.
“Squad management is going to be very important to us.
“We have to assess the players after the impact the Fleetwood game will have on Saturday.
“We need to see what’s available and what’s the best possible team that we put together for the Oldham game so the squad will be very, very active this week.”
Fleetwood travel to Derbyshire on the back of three straight losses.
However, Wilson still expects a tough assignment from Steven Pressley’s side.
He added: “I’m expecting a very good game.
“I’m expecting a determined team.
“I don’t think for one minute it will be a defensive game.
“I think they’ll come out and try to attack us.
“We’ll do the same with them so it’s going to be a good, tight game but quite open.”