Terrell Forbes bagged a late winner as managerless Spireites edged a seven-goal thriller to secure back-to-back home wins.
Chesterfield were two up inside 11 minutes with goals from strikers Jack Lester and Marc Richards but the visitors, unbeaten away, hit back to level through Rommy Boco and Peter Murphy. Lester and Boco both made it braces before Michael Liddle was dismissed and the hosts nicked the winner.
With triallist Etienne Esajas in the stands, Charlie Barnett clipped the bar for the visitors, who were then soon behind, unsurprisingly after a defensive mistake. Luke Joyce badly misjudged a back header and Lester found himself in space, inside the box.
Goalkeeper Ian Dunbavin was ahead of the wily 36 year-old who casually chipped the ball and the crowd collectively groaned as the ball seemed destined to be caught by one of their number, only for glumness to turn to cheers as the ball dipped in just below the bar.
Lester then turned provider, crossing in for Richards to head home to get off the mark for Chesterfield. The striker was subsequently mobbed by his team-mates after his goal-drought.
Richards had the ball in the net again, but it appeared to come off his shoulder and within 30 seconds what could have been 3-0 turned to 2-1 as Barnett crossed for Boco to glance a header beyond Richard O’Donnell.
Barnett, easily Stanley’s top operator, burst through a hesitant back-line to shoot from an angle but Sam Hird blocked with his chest a yard out. Somewhat surprisingly, soon after the break, he was subbed as the visitors made a double switch to give debuts to a pair of players borrowed from Watford.
However the switch had the desired effect as Sam Whichelow crossed deep for Murphy to score from close in at the far post.
Chesterfield’s subsequent personnel change also did the job. Tendayi Darikwa, on the right wing, crossed in and there was Lester to receive, turn and score from six yards. Stanley boss Paul Cook was livid as Lester clearly handballed in the build-up.
His disappointment was short-lived as Boco gathered, ran and shot a fine solo goal to level things up once again.
Defender Liddle was shown a straight red for a foul on Lester seven minutes from time and it took less than a minute for defender Forbes to win it, shooting at the second bite after Lester crossed in.
CHESTERFIELD (4-4-2): O’Donnell 6, Forbes 7, Trotman 6, Hird 6, Ridehalgh 6, Talbot 7, Atkinson 6 (Randall 88), Togwell 6, Westcarr 6 (Darikwa 63, 7), Lester 8 (Allott 88), Richards 7. Subs (not used): Wilson, Clay, Boden, Hazel.
Goals: Lester 8, 66, Richards 11, Forbes 84
ACCRINGTON (4-5-1): Dunbavin 6, Lindfield 6, Nsiala 6, Murphy 6, Liddle 6, Barnett 8 (Mingoia 55, 6), Joyce 5, Schofield 6, Boco 8, Molyneux 6 (Whichelow 55, 7), Amond 6 (Sheppard 74). Subs (not sued): Dawber, Eckersley, Dixon, Hatfield.
Goals: Boco 28, 76, Murphy 58
Referee: Craig Pawson (South Yorks)