Injured duo Ollie Banks and Drew Talbot are making good progress, said Chesterfield goalkeeping coach Eric Nixon.
Banks had an operation this week to remove pins from the broken bone in his foot while Talbot is also understood to be making strides.
Goalkeeper Aaron Chapman made a return to action alongside a youthful Spireites side at Dronfield Town on Friday night and came through it unscathed.
Charlie Dawes found the back of the net twice in a 3-2 victory at their NCEL Division One opponents.
Chapman is expected to be on the bench when Chesterfield visit Leyton Orient on Saturday (August 9) in their first game of the League One season.
Following the 3-1 win over Aston Villa, Nixon was hopeful some of the injured players would make a return: “They aren’t too far off. Drew’s a while away but the likes of Ollie and Aaron are raring to go.”
It will be a tough test for the Spireites against a side that also graced the Wembley turf last season when they were beaten League One play-off finalists.
The Orient have since had a change in ownership when Barry Hearn sold the club to Italian businessman Francesco Becchetti who has appointed a new chief executive and sporting director.
Orient boss Russell Slade (pictured) has been well supported in the transfer market with the additions of Darius Henderson, Jobi McAnuff and Jay Simpson a select few.
A Jimmy Juan goal gave Chesterfield a point the last time they visited Brisbane Road after David Mooney had put the Orient ahead.
Orient edge the head-to-heads but Spireites winger Gary Roberts said the League Two champions have nothing to fear.
He said: “I think Leyton Orient will have a good year. They haven’t really splashed the cash in the past but with new owners they have signed some really good players.
“Some of their signings who have dropped down to this level have surprised a few. They will be looking to beat us but we’ve got good players ourselves.”