Sam Hird captains the side in the absence of midfielder Gary Liddle.
Liddle was shown a straight red card against Colchester United midweek and the club’s subsequent appeal was turned down.
Spireites: Lee, Talbot, Hird (c), Anderson, John, Ariyibi, Damaio, Herd, Banks, Ebanks-Blake, Novak
Subs: O’Shea, Humphreys, Donohue, Chapman, Simons, Dieseruvwe, Slew
Crewe: Garratt, Turton, Nugent, Ajayi, Guthrie, Fox (c), Jones, Inman, Bakayogo, Haber, Saunders
Subs: Richards, NG, Ainley, Kirk, Kearns, Howell, Finney
Referee: Gavin Ward