Delays are expected after a crash involving two vehicles between Bakewell and Baslow.
Police received a call to attend the A619, known locally as the 13 bends, at 11.30am.
The vehicles involved are a Mercedes Sprinter van and a VW T5 California.
There are no injuries as a result of the collision.
Recovery is taking place.
Traffic is likely to be heavy in the area so if people can use a different route then they should, a spokesperson for Derbyshire police said.