A motorcyclist has been rushed to hospital after a serious collision on the A38 between Belper and Ripley.
Traffic has been at a standstill on the busy stretch of dual-carriageway between Ripley and Coxbench.
The motorcyclist involved in the crash has been rushed to hospital with serious injuries after colliding with a car.
Derbyshire police said: "A collision between Ripley and Coxbench is causing traffic chaos. The A38 southbound is closed and traffic is tailing back to Watchorn island at Alfreton.
"The incident occurred at 8.50am this morning involving a car and motorcycle.
"The rider of the motorcycle has been taken to Queen's Medical Centre in Nottingham with serious injuries, but not thought to be life threatening, and we are working with Highways to remove the backlog of vehicles and get the road clear."
There is still a heavy amount of traffic so drivers should avoid the area if possible.
Traffic updates show the southbound carriageway is still stationary after the incident between the A610 junction and the B6374 junction at Ripley Road. Travel time is around 20 minutes and a diversion is in operation via the A610.