Wayne Pickford was last seen in the Clarence Road area of Long Eaton at 2.20pm on Wednesday, June 22.
The 45-year-old, who is 6ft tall, of slim build, and has short brown hair, was wearing all black clothing with a silver chain.
Officers say they are concerned for Wayne, who is also known to frequent the Derby city centre area.
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Anyone with any information about his current whereabouts is asked to contact Derbyshire police using any of the below methods, including reference 607-230622:
Facebook – send us a private message to /DerbyshireConstabulary
Twitter – direct message the force’s contact centre via @DerPolContact
Website – complete the online contact form
Phone – call 101