Odyssey will launch in the old Queen’s Head pub building on September 20.
Owned by a Greek family now based in Chesterfield, the eatery aims to fill a gap in the market in the town.
It hopes to combine traditional English architecture with Greek hospitality, culture, taste and cuisine.
Konstantinos Diamantidis, of the restaurant, said: “My grandmother used to say that there is nothing better than homemade food and taught us to eat and cook only the best.
“Now, years later, we as a family will try to give you a taste of what Greek families believe good-quality Greek food tastes like.”
The Queen’s Head pub has been closed for several years.