More than 1,200 fundraisers are set to walk, jog and run through Chesterfield town centre for the annual Race for Life cause.
The Cancer Research UK event will start at the town hall at 10.30am on Sunday.
Councillor Amanda Serjeant, Chesterfield Borough Council’s cabinet member for town centre and visitor economy, said: “We are pleased to once again support Chesterfield’s Race for Life event because it is such a worthwhile cause.
“All of us will have been touched by cancer at some time in our lives either through having the disease or knowing someone who has.
“There may be some disruption in the town centre during the race but we will keep this to a minimum.
“Roads and car parks will open as soon as possible after the race participants have passed.
“Good luck to everyone in the race,” she added.
To enable the event to run smoothly, the borough council will temporarily close Queen’s Park North car park, Rose Hill car park and Albion Road car park.
Soresby Street car park will also open only for participants in the event.
It will reopen to the public once the race is finished.
Several roads around the town centre including around the Town Hall, Knifesmithgate, Elder Way, around the Crooked Spire church and sections of West Bars, New Beetwell Street, Boythorpe Avenue and Park Road will also be closed for periods between early morning and early afternoon while the race takes place.