A driver is in hospital with serious injuries after their car left the Dronfield bypass.
The silver Seat Ibiza left the A61 carriageway and landed near Gosforth Drive during the early hours of Saturday morning.
The bypass was closed between Whittington Moor and Bowshaw for several hours to allow for collision investigation work.
Police, paramedics and firefighters all attended the incident.
A spokesperson for Derbyshire Fire and Rescue Service said crews helped to release one male casualty from the car.
Witnesses to the crash are being urged to call Derbyshire Constabulary on 101.