Paul Cook has indicated that injured trio Gary Roberts, Sam Morsy and Dan Jones could be back in contention for the visit of Sheffield United.
The Spireites boss was forced in to changes for last Saturday’s derby clash with Notts County due to recent injuries to hit his squad.
Cook opted to go 4-4-2, rather than his preferred 4-2-3-1, and to not risk the players he said were nearing a return to action last week.
But he may be tempted to throw them in if 100 per cent for the visit of another local rival to the Proact Stadium in a 1pm kick-off on Saturday.
He will be hoping his side have better luck in front of goal than they did against Notts, who had veteran keeper Roy Carroll to thank for a point.
Armand Gnanduillet, Jay O’Shea, Ollie Banks were chosen for the visit of Notts, while Georg Margreitter returned from a concussion.
Dan Gardner also made an impact from the substitutes bench, giving reason to recent calls from Cook that the midfielder is raring to go ahead of a tasty month ahead.
It all starts on Saturday with the visit of Nigel Clough’s Blades side, who, despite a rocky start to the season, having lost their first two games, have picked up of late.
United have won five of their last seven, losing just once - a 5-2 defeat to Swindon Town on September 20 - and boast one time Blues target Michael Higdon in attack.
The last time the two sides met in Chesterfield on November 26, 2011, Ched Evans grabbed a winner eight minutes from time.