Police are asking residents to call them if they come across large containers of a tar-like substance, which may have been stolen from a former industrial site in Staveley.
Twenty 50 litre containers have gone missing from a former business in Hall Lane.
Police believe they may have been stolen and if the chemical inside is ingested, it may make you sick.
The black plastic containers are around 18 inches tall and have screw tops.
Anyone with information, or anyone who discovers these containers, should call police on 101.