The A515 at Newhaven is closed following a collision between a car and a motorcycle.
The collision took place between a Toyota Aygo and Honda motorcycle at 1.45pm.
Police closed the road in both directions from just after the garage at Newhaven and just beyond Parsley Hay as the fire service and air ambulance attended the scene.
The condition of a male motorcyclist is currently unknown.
Further updates to follow.