A seven-year-old girl escaped from the house blaze which killed two young boys and two women - and was found by firefighters in the garden.
She is now recovering in hospital after suffering just minor injuries.
Police and fire services have launched a joint investigation into the deaths of four people who perished in the house fire today.
At a press conference this afternoon, Derbyshire Fire Service’s area manager Kam Basi said: “On behalf of the fire service our thoughts and prayers go to the family concerned.
“We got a call at 5am this morning and mobilised two appliances, one from Clay Cross and one from Chesterfield, and another appliance from Staveley came later.
“Firefighters battled arduous smoke-logged conditions and four people were carried out - unfortunately they had perished through the fire.
“Four deceased were rescued and one young girl was found in the garden having made her escape.
“We believe the seven-year-old girl made her way out before the fire services arrived.”
Chief Inspector Rick Gooch told the press conference, held at the scene of the blaze: “A call came in from a neighbour and police and fire were requested to attend the house where four people have tragically died.
“I can confirm that two were women and two were young children, all taken to hospital where they were pronounced dead.
“Also a seven-year-old survived the fire and has minor injuries consistent with smoke inhalation.
“I can give you reassurances that police and fire services are trying to establish the cause of the fire.
“It is a tragic event and the impact on the community is recognised.
“Specially trained officers are working with family and we are still working to identify the individuals concerned.”
Police and fire services are not confirming at this stage whether the fire was started deliberately.